mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate
Nutrient sensing by mechanistic target of rapamycin complex 1 (mTORC1) on lysosomes and late endosomes (LyLEs) regulates cell growth. Many factors stimulate mTORC1 activity, including the production of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] by class I phosphatidylinositol 3-kinases (...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
The American Association for the Advancement of Science
2017
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| Online Access: | http://hdl.handle.net/20.500.11937/54003 |