Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition
Poly-S-nitrosated human serum albumin (Poly-SNO-HSA) delivered and accumulated nitric oxide (NO) in tumors and induces apoptosis. Tumor hypoxia is strongly associated with malignant progression and tumor resistance to therapy. In this study, we examined the cytotoxic effect of Poly-SNO-HSA under hyp...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Inc
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/53941 |