Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis
This research describes the exploration of a new scaffold with the potential to be developed in to a new drug for the treatment of Human African Trypanosomiasis (HAT), a neglected disease endemic in sub-Saharan Africa. Derivatives of an isoquinoline scaffold were synthesised and evaluated for their...
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| Format: | Thesis |
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Curtin University
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/52988 |
| _version_ | 1848759052889227264 |
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| author | Cullen, Danica Renae |
| author_facet | Cullen, Danica Renae |
| author_sort | Cullen, Danica Renae |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This research describes the exploration of a new scaffold with the potential to be developed in to a new drug for the treatment of Human African Trypanosomiasis (HAT), a neglected disease endemic in sub-Saharan Africa. Derivatives of an isoquinoline scaffold were synthesised and evaluated for their in vitro activity against T.b.rhodesiense, the causative agent of HAT. Five derivatives were identified with inhibition of T.b.rhodesiense in the sub-micromolar range with good selectivity over mammalian cells. |
| first_indexed | 2025-11-14T09:53:45Z |
| format | Thesis |
| id | curtin-20.500.11937-52988 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:53:45Z |
| publishDate | 2016 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-529882018-06-20T04:59:48Z Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis Cullen, Danica Renae This research describes the exploration of a new scaffold with the potential to be developed in to a new drug for the treatment of Human African Trypanosomiasis (HAT), a neglected disease endemic in sub-Saharan Africa. Derivatives of an isoquinoline scaffold were synthesised and evaluated for their in vitro activity against T.b.rhodesiense, the causative agent of HAT. Five derivatives were identified with inhibition of T.b.rhodesiense in the sub-micromolar range with good selectivity over mammalian cells. 2016 Thesis http://hdl.handle.net/20.500.11937/52988 Curtin University fulltext |
| spellingShingle | Cullen, Danica Renae Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis |
| title | Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis |
| title_full | Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis |
| title_fullStr | Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis |
| title_full_unstemmed | Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis |
| title_short | Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis |
| title_sort | development of tetrahydroisoquinoline analogues: towards a treatment for human african trypanosomiasis |
| url | http://hdl.handle.net/20.500.11937/52988 |