Synthesis, Stereochemistry and Antiparasitic Activity of Derivatives of (4R)-4,6-Dihydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline

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Synthesis, Stereochemistry and Antiparasitic Activity of Derivatives of (4R)-4,6-Dihydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline

Condensation of phenylephrine with different aldehydes, under Pictet-Spengler cyclisation conditions, afforded a series of tetrahydroisoquinoline derivatives as mixtures of cis/trans isomers. Single crystal X-ray analysis of the dibenzoate derivative of one of the 4-nitrophenyl isomers confirmed it...

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Bibliographic Details
Main Authors:	Cullen, Danica, Pengon, J., Rattanajak, R., Chaplin, J., Kamchonwongpaisan, S., Massera, C., Mocerino, Mauro, Rohl, Andrew
Format:	Journal Article
Published:	Wiley - V C H Verlag GmbH & Co. KGaA 2017
Online Access:	http://hdl.handle.net/20.500.11937/52521

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