Scoping Studies into the Structure-Activity Relationship (SAR) of Phenylephrine-Derived Analogues as Inhibitors of Trypanosoma brucei rhodesiense

QR Code

Scoping Studies into the Structure-Activity Relationship (SAR) of Phenylephrine-Derived Analogues as Inhibitors of Trypanosoma brucei rhodesiense

Human African Trypanosomiasis (HAT) is a disease caused by the parasite Trypanosoma brucei and is classified as a neglected tropical disease of concern in sub-Saharan Africa. A scoping study has been undertaken to develop a preliminary structure activity relationship of a tetrahydroisoquinoline scaf...

Full description

Bibliographic Details
Main Authors:	Cullen, Danica, Pengon, J., Rattanajak, R., Chaplin, J., Kamchonwongpaisan, S., Mocerino, Mauro
Format:	Journal Article
Published:	Wiley - V C H Verlag GmbH & Co. KGaA 2016
Online Access:	http://hdl.handle.net/20.500.11937/51609

Similar Items

(+)-Spectaline and iso-6-spectaline induce a possible cross-talk between autophagy and apoptosis in Trypanosoma brucei rhodesiense
by: Lim, Kah Tee, et al.
Published: (2019)

Synthesis, Stereochemistry and Antiparasitic Activity of Derivatives of (4R)-4,6-Dihydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline
by: Cullen, Danica, et al.
Published: (2017)

High-Throughput Screening Assay In 384-Well Format For The Identification Of Anti-Trypanosomal Agents Against Trypanosoma Brucei Rhodesiense And Mode Of Cell Death Study
by: Lim, Kah Tee
Published: (2017)

Dissection of flagellar pocket function in Trypanosoma brucei
by: Whipple, Sarah
Published: (2018)

Essential or redundant? Disentangling the (GR)ESAG families of Trypanosoma brucei
by: Chamberlain, James W.
Published: (2018)

The heart of darkness : growth and form of Trypanosoma brucei in the tsetse fly.
by: Kumar Sharma, Reuben Sunil, et al.
Published: (2009)

Identification of the meiotic life cycle stage of Trypanosoma brucei in the tsetse fly.
by: Peacock, L., et al.
Published: (2011)

Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo
by: Ahmad Fuad, Fazia Adyani
Published: (2011)

Exploring the surface of Trypanosoma brucei through protein sorting and recombinant expression
by: Miller, Thomas
Published: (2020)

Identification of the ISWI chromatin remodeling complex of the early branching Eukaryote Trypanosoma brucei
by: Stanne, Tara, et al.
Published: (2015)

A brief review of drug discovery research for Human African Trypanosomiasis
by: Cullen, Danica, et al.
Published: (2017)

Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis
by: Cullen, Danica Renae
Published: (2016)

Functional characterisation of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages.
by: Sharma, Reuben Sunil Kumar, et al.
Published: (2008)

Evaluation of ocular biometry parameters before and after instillation of tropicamide 1.0%, phenylephrine 2.5% and combination of tropicamide 1.0%-phenylephrine 2.5% eye drops
by: Yee, Chong Soh
Published: (2018)

Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

Synthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

The synthesis and testing of novel analogues of (+)-ambuic acid as inhibitors of staphylococcal virulence
by: Reekes, James
Published: (2021)

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)

Lignocaine/phenylephrine nasal spray vs. placebo for the pain and distress of nasogastric tube insertion in children: A study protocol for a randomized controlled trial
by: Craig, S., et al.
Published: (2015)

Jangkitan trypanosoma lewisi pada tikus liar
by: Zainal-Abidin Abu Hasan,, et al.
Published: (1999)

Prevalence of Trypanosoma Evansi in Horses in Peninsular Malaysia.
by: Kumar, Amit
Published: (2009)

Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
by: Rullah, Kamal, et al.
Published: (2019)

Molecular docking unveils prospective inhibitors for the SARS-COV-2 main protease
by: Ahmad, Fawad, et al.
Published: (2021)

Response of inbred mice to infection with a new isolate of Trypanosoma musculi
by: Chiejina, S.N., et al.
Published: (1993)

Genetic diversity and antigenic variation of trypanosoma evansi in Malaysia
by: Watanabe, Mahira
Published: (2012)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
by: Mohd Faudzi, S. M., et al.
Published: (2015)

Epidemiology of Trypanosoma evansi Infection in Crossbred Dairy Cattle in Malaysia
by: Cheah, Tong Soon, et al.
Published: (1999)

Epidemiology, Diagnosis And Chemoprophylaxis Of Trypanosoma Evansi Infection In Dairy Cattle
by: Cheah, Tong Soon
Published: (1997)

Epidemiology of Trypanosoma evansi infection in crossbred dairy cattle in Malaysia
by: Cheah, T.S., et al.
Published: (1999)

Analogues of 2-Deoxyglucose as inhibitor candidates for hexokinase II identified via virtual screening analyses
by: Tanbin, Suriyea, et al.
Published: (2018)

The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors
by: Szabo, M., et al.
Published: (2011)

Allicin-induced cellular destruction of haemoflagellate protozoa, Trypanosoma evansi in mice
by: Abu Hassan, Zainal Abidin, et al.
Published: (2011)

Allicin-induced cellular destruction of haemoflagellate protozoa, trypanosoma evansi in mice
by: Zainal-Abidin .B.A.H,, et al.
Published: (2011)

Comparative diagnosis, pathogenicity and immunosuppressive effect of trypanosoma evansi infection in goats
by: Abdubakar Anka 1, Ibrahim
Published: (2012)

Pathogenesis of nephro-and testiculopathies induced by the Malaysian isolate of Trypanosoma evansi in rabbits
by: Gumar, Yasameen Sahib
Published: (2015)

Seroprevalence and risk factors of Trypanosoma evansi infection in horses in Peninsular Malaysia
by: Elshafie, E. I., et al.
Published: (2013)

Identification of SARS-CoV-2 inhibitors from alkaloids using molecular modeling and in silico approaches
by: Roni, Md Abul Hasan, et al.
Published: (2023)

Pathogenic effects and prepatent periods of Trypanosoma evansi isolates from Indonesia in mice
by: Sawitri, Dyah H., et al.
Published: (2022)

Probing the system behind variable antigen expression in animal pathogen Trypanosoma congolense
by: McDonald, Jennifer
Published: (2018)

Prevalence of bovine haemoparasites and risk factors associated with Trypanosoma evansi infection in Malaysia
by: Md Isa, Nur Mahiza
Published: (2010)