The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88

The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88

Sepsis is one of the most challenging health problems worldwide. Here we found that phagocytes from patients with sepsis had considerable upregulation of Toll-like receptor 4 (TLR4) and TLR2; however, shock-inducing inflammatory responses mediated by these TLRs were inhibited by ES-62, an immunomodu...

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Bibliographic Details
Main Authors: Puneet, P., McGrath, M., Tay, H., Al-Riyami, L., Rzepecka, J., Moochhala, S., Pervaiz, Shazib, Harnett, M., Harnett, W., Melendez, A.
Format: Journal Article
Published: Nature Publishing Group 2011
Online Access:http://hdl.handle.net/20.500.11937/51243

Internet

http://hdl.handle.net/20.500.11937/51243

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