QR Code

A distinct reactive oxygen species profile confers chemoresistance in glioma-propagating cells and associates with patient survival outcome

Aims: We explore the role of an elevated O2-:H 2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers. Results: We observed that an elevated O2-:H2O2 ratio conferred enhanced resistance in GPCs, and depleti...

Full description

Bibliographic Details
Main Authors:	Koh, L., Koh, G., Ng, F., Toh, T., Sandanaraj, E., Chong, Y., Phong, M., Tucker-Kellogg, G., Kon, O., Ng, W., Ng, I., Clement, M., Pervaiz, Shazib, Ang, B., Tang, C.
Format:	Journal Article
Published:	Mary Ann Liebert, Inc. Publishers 2013
Online Access:	http://hdl.handle.net/20.500.11937/51146

Similar Items

Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511
by: Tucker-Kellogg, L., et al.
Published: (2012)

FLIP: A flop for execution signals
by: Subramaniam, K., et al.
Published: (2013)

The three Rs along the TRAIL: Resistance, re-sensitization and reactive oxygen species (ROS)
by: Mellier, G., et al.
Published: (2012)

Conference roundup MAC 2011
by: Pervaiz, Shazib
Published: (2013)

Colon cancer chemoresistance and chemosensitization
by: Shanmugam, M., et al.
Published: (2018)

Reactive oxygen species and oncoprotein signaling-a dangerous liaison
by: Chong, S., et al.
Published: (2018)

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
by: Shi, Y., et al.
Published: (2013)

Molecular and cellular mechanisms of chemoresistance in pancreatic cancer
by: Adamska, Aleksandra, et al.
Published: (2018)

Dysregulation of Nrf2 in hepatocellular carcinoma: Role in cancer progression and chemoresistance
by: Raghunath, A., et al.
Published: (2018)

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance.
by: Begicevic, R., et al.
Published: (2017)

A study of distinctive features of Penang Hokkien in Malaysia.
by: Ng, Boon Sim
Published: (2013)

Reactive oxygen species level defines two functionally distinctive stages of inflammatory dendritic cell development from mouse bone marrow
by: Sheng, K., et al.
Published: (2010)

Specialisation within the DWARF14 protein family confers distinct responses to karrikins and strigolactones in Arabidopsis
by: Waters, M., et al.
Published: (2012)

Na+/H+ exchanger 1 (NHE-1) redox-regulated gene and intracellular target for the redox control of cell death sensitivity
by: Akram, S., et al.
Published: (2011)

Exploring the role of multidrug exporters and extracellular vesicles in medulloblastoma chemoresistance
by: Wade, Philippa
Published: (2024)

NGAL is downregulated in oral squamous cell carcinoma and leads to increased survival, proliferation, migration and chemoresistance
by: Monisha, J., et al.
Published: (2018)

Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress
by: Ip, Carman K.M., et al.
Published: (2016)

Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease
by: Peace, A., et al.
Published: (2008)

Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion.
by: Tochhawng, L., et al.
Published: (2016)

Fluorescence guided versus conventional surgical resection of high grade glioma : a single centre 7 year comparative effectiveness study
by: Ping, Ng Wei
Published: (2016)

Keluarga astrositoma dan glioma
by: Awang, Mohamed Saufi
Published: (2012)

Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer
by: Elaskalani, O., et al.
Published: (2017)

Establishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemia
by: Panting, Rhiannon
Published: (2024)

Volatile-char interactions: Roles of in situ volatiles with distinctly-different chemistry in determining char structure and reactivity
by: Chen, X., et al.
Published: (2018)

Characterization and chemoresistance of HT29 (Colon cancer) and TW06 (Nasopharyngeal cancer) tumorspheres
by: Goh, Iris Wen Li
Published: (2014)

Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas
by: Hirpara, J., et al.
Published: (2016)

Redox pioneer: Professor Barry Halliwell
by: Pervaiz, Shazib
Published: (2011)

Redox Dichotomy in Cell Fate Decision: Evasive Mechanism or Achilles Heel?
by: Pervaiz, Shazib
Published: (2018)

Analysis between eating behaviour and the emotional eating scale scores from emotional eating scale among overweight students in UNIMAS
by: Ng, Koh Ing
Published: (2009)

Identification of missense mutations in genes related to cancer pathways in glioma
by: Nor Azian Abdul Murad,, et al.
Published: (2016)

Characterisation of tumorspheres generated from nasopharyngeal carcinoma cell line TW06 and chemoresistance to docetaxel
by: Goh, Iris Wen Li, et al.
Published: (2015)

Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2021)

Breast Cancer: A Molecular and Redox Snapshot
by: Raman, D., et al.
Published: (2016)

The prognostic value of perfusion MRI in cerebral glioma
by: Manita, Muftah
Published: (2012)

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
by: Mayola, E., et al.
Published: (2011)

Distinctive Design
by: Farren, Anne
Published: (2008)

Criteria For Distinction
by: New Straits Times,
Published: (2008)

Combatting chemoresistance: an analysis of DNA repair proteins ERCC1 and XPF and their chemotherapeutic implications in ovarian cancer
by: Griffin, Michaela
Published: (2019)

Characterization of tumorspheres generated from nasopharyngeal carcinoma cell line, TW06 and chemoresistance to docetaxel and oxaliplatin
by: Goh, Iris Wen Li, et al.
Published: (2015)

The molecular and phenotypic basis of the glioma invasive perivascular niche
by: Diksin, Mohammed, et al.
Published: (2017)