A distinct reactive oxygen species profile confers chemoresistance in glioma-propagating cells and associates with patient survival outcome

A distinct reactive oxygen species profile confers chemoresistance in glioma-propagating cells and associates with patient survival outcome

Aims: We explore the role of an elevated O2-:H 2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). We hypothesize that depleting this ratio sensitizes GPCs to apoptotic triggers. Results: We observed that an elevated O2-:H2O2 ratio conferred enhanced resistance in GPCs, and depleti...

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Bibliographic Details
Main Authors: Koh, L., Koh, G., Ng, F., Toh, T., Sandanaraj, E., Chong, Y., Phong, M., Tucker-Kellogg, G., Kon, O., Ng, W., Ng, I., Clement, M., Pervaiz, Shazib, Ang, B., Tang, C.
Format: Journal Article
Published: Mary Ann Liebert, Inc. Publishers 2013
Online Access:http://hdl.handle.net/20.500.11937/51146

Internet

http://hdl.handle.net/20.500.11937/51146

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