Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 d stabilizes its antiapoptotic activity

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Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 d stabilizes its antiapoptotic activity

Bcl-2 is frequently overexpressed in hematopoietic malignancies, and selective phosphorylation at ser70 enhances its antiapoptotic activity. Phospho-ser70 is dephosphorylated by specific heterotrimers of protein phosphatase 2A (PP2A). We report here that a mild pro-oxidant intracellular milieu induc...

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Bibliographic Details
Main Authors:	Low, I., Loh, T., Huang, Y., Virshup, D., Pervaiz, Shazib
Format:	Journal Article
Published:	American Society of Hematology 2014
Online Access:	http://hdl.handle.net/20.500.11937/51027

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