Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 d stabilizes its antiapoptotic activity
Bcl-2 is frequently overexpressed in hematopoietic malignancies, and selective phosphorylation at ser70 enhances its antiapoptotic activity. Phospho-ser70 is dephosphorylated by specific heterotrimers of protein phosphatase 2A (PP2A). We report here that a mild pro-oxidant intracellular milieu induc...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
American Society of Hematology
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/51027 |