The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

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The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

The small GTPase Rac1 is involved in the activation of the reduced NAD phosphate oxidase complex resulting in superoxide production.We recently showed that Bcl-2 overexpression inhibited apoptosis in leukemia cells by creating a pro-oxidant intracellular milieu, and that inhibiting intracellular sup...

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Bibliographic Details
Main Authors:	Velaithan, R., Kang, J., Hirpara, J., Loh, T., Goh, B., Le Bras, M., Brenner, C., Clement, M., Pervaiz, Shazib
Format:	Journal Article
Published:	American Society of Hematology 2011
Online Access:	http://hdl.handle.net/20.500.11937/51018

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