The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity
The small GTPase Rac1 is involved in the activation of the reduced NAD phosphate oxidase complex resulting in superoxide production.We recently showed that Bcl-2 overexpression inhibited apoptosis in leukemia cells by creating a pro-oxidant intracellular milieu, and that inhibiting intracellular sup...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Published: |
American Society of Hematology
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/51018 |