Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

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Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

Using a screen for Wnt/β-catenin inhibitors, a family of 8-hydroxyquinolone derivatives with in vivo anti-cancer properties was identified. Analysis of microarray data for the lead compound N-((8-hydroxy-7-quinolinyl) (4-methylphenyl)methyl)benzamide (HQBA) using the Connectivity Map database sugges...

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Bibliographic Details
Main Authors:	Coombs, G., Schmitt, A., Canning, C., Alok, A., Low, I., Banerjee, N., Kaur, S., Utomo, V., Jones, C., Pervaiz, Shazib, Toone, E., Virshup, D.
Format:	Journal Article
Published:	Nature Publishing Group 2012
Online Access:	http://hdl.handle.net/20.500.11937/50895

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