Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
Using a screen for Wnt/β-catenin inhibitors, a family of 8-hydroxyquinolone derivatives with in vivo anti-cancer properties was identified. Analysis of microarray data for the lead compound N-((8-hydroxy-7-quinolinyl) (4-methylphenyl)methyl)benzamide (HQBA) using the Connectivity Map database sugges...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/50895 |