Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production

Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production

© 2016 Mary Ann Liebert, Inc. We recently reported the death-inducing activity of a small-molecule compound, C1, which triggered reactive oxygen species (ROS)-dependent autophagy-associated apoptosis in a variety of human cancer cell lines. In this study, we examine the ability of the compound to sp...

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Bibliographic Details
Main Authors: Iskandar, K., Rezlan, M., Yadav, S., Foo, C., Sethi, G., Qiang, Y., Bellot, G., Pervaiz, Shazib
Format: Journal Article
Published: Mary Ann Liebert, Inc. Publishers 2016
Online Access:http://hdl.handle.net/20.500.11937/50816

Internet

http://hdl.handle.net/20.500.11937/50816

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