A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

A prior screening programme carried out using MTT assay by our group identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2- hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cisp...

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Bibliographic Details
Main Authors: Dai, X., Wang, L., Deivasigamni, A., Looi, C., Karthikeyan, C., Trivedi, P., Chinnathambi, A., Alharbi, S., Arfuso, Frank, Dharmarajan, Arunasalam, Goh, B., Hui, K., Kumar, Alan Prem, Mustafa, M., Sethi, Gautam
Format: Journal Article
Published: Impact Journals LLC 2017
Online Access:http://hdl.handle.net/20.500.11937/50403

Internet

http://hdl.handle.net/20.500.11937/50403

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