Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV 1.7

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV 1.7

ProTx-II is a disulfide-rich peptide toxin from tarantula venom able to inhibit the human voltage-gated sodium channel 1.7 (hNaV 1.7), a channel reported to be involved in nociception, and thus it might have potential as a pain therapeutic. ProTx-II acts by binding to the membrane-embedded voltage s...

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Bibliographic Details
Main Authors: Henriques, S., Deplazes, Evelyne, Lawrence, N., Cheneval, O., Chaousis, S., Inserra, M., Thongyoo, P., King, G., Mark, A., Vetter, I., Craik, D., Schroeder, C.
Format: Journal Article
Published: The American Society for Biochemistry and Molecular Biology Inc 2016
Online Access:http://hdl.handle.net/20.500.11937/50328

Internet

http://hdl.handle.net/20.500.11937/50328

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