Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

QR Code

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

Celastrol, a plant triterpene has attracted great interest recently, especially for its potential anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect of celastrol on proliferation of various cancer cell lines. The mechanism, by which this triterpene exerts...

Full description

Bibliographic Details
Main Authors:	Kannaiyan, R., Manu, K., Chen, L., Li, F., Rajendran, P., Subramaniam, A., Lam, P., Kumar, Alan Prem, Sethi, G.
Format:	Journal Article
Published:	Springer 2011
Online Access:	http://hdl.handle.net/20.500.11937/50124

Similar Items

Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo
by: Rajendran, P., et al.
Published: (2012)

Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway
by: Castresana, Javier S., et al.
Published: (2017)

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
by: Kannaiyan, R., et al.
Published: (2011)

Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
by: Shanmugam, M., et al.
Published: (2018)

Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor [gamma] Activation Pathway in Gastric Cancer
by: Ramachandran, L., et al.
Published: (2012)

Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model
by: Shanmugam, M., et al.
Published: (2015)

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
by: Shanmugam, M., et al.
Published: (2012)

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
by: Singh, S., et al.
Published: (2015)

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation
by: Smit, L., et al.
Published: (2015)

Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer (Journal of Biological Chemistry (2012) 287, (38028-38040))
by: Ramachandran, L., et al.
Published: (2013)

Akt/protein kinase B in skeletal muscle physiology and pathology
by: Wu, M., et al.
Published: (2011)

Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor‐related apoptosis‐inducing ligand
by: Harith, Hanis Hazeera, et al.
Published: (2016)

Regulation of phosphatidylinositol 3-kinase (PI3K/Akt) pathway in chicken and duck cells and its implications for influenza A virus pathogenesis
by: Kumar, Sanjeeva
Published: (2018)

Elucidation of the WNT & AKT/Phosphoinositide-3-Kinase Pathways in Colorectal Carcinoma
by: Khor, Tin Oo
Published: (2004)

PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells
by: Chen, J., et al.
Published: (2015)

Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: The role of p38 MAPK and ROS
by: Woo, C., et al.
Published: (2013)

Effects of albumin–chlorogenic acid nanoparticles on apoptosis and PI3K/Akt/mTOR pathway inhibitory activity in MDA-MB-435s cells
by: Alzahrani, Badr, et al.
Published: (2023)

Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway
by: Edling, C., et al.
Published: (2014)

Tualang honey promotes apoptosis of the A549 lung adenocarcinoma cell line via modulation of PI3K/AKT signaling pathway-related proteins
by: Nazirah A,, et al.
Published: (2022)

The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation
by: Yap, Hui Min, et al.
Published: (2018)

Brewers’ rice induces apoptosis in azoxymethane-induced colon carcinogenesis in rats via suppression of cell proliferation and the Wnt signaling pathway
by: Tan, Bee Ling, et al.
Published: (2014)

Erratum: Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-?B activation in breast and pancreatic tumor cells (Biochemical Pharmacology (2010) 80 (1553-1562))
by: Chua, A., et al.
Published: (2014)

Sodium alginate encapsulated iron oxide decorated with thymoquinone nanocomposite induces apoptosis in human breast cancer cells via PI3K-Akt-mTOR pathway
by: Alzahrani, Badr, et al.
Published: (2023)

Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2021)

Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway
by: Chen, Jichao, et al.
Published: (2017)

Nanocomposites of iron oxide, sodium alginate, and eugenol induce apoptosis via PI3K/Akt/mTOR signaling in Hep3 cells and in vivo hepatotoxicity in the zebrafish model
by: Elderdery, Abozer Y., et al.
Published: (2024)

Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma
by: Huang, B., et al.
Published: (2016)

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
by: Rajendran, P., et al.
Published: (2012)

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
by: Dai, X., et al.
Published: (2017)

Suppression of essential pro-inflammatory signaling pathways by natural agents for the therapy of Multiple Myeloma
by: Sikka, S., et al.
Published: (2014)

Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer
by: Zhang, J., et al.
Published: (2017)

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
by: Shanmugam, M., et al.
Published: (2011)

Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA
by: Chaudhry, Gul E. Saba, et al.
Published: (2020)

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
by: Shanmugam, M., et al.
Published: (2011)

Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma
by: Abbhi, V., et al.
Published: (2017)

A Potential Effect of Cordycepin on the Feedback between Polyadenylation and PI3K/Akt/mTOR Signalling
by: Lawrence, Steven
Published: (2023)

Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
by: Rajendran, P., et al.
Published: (2011)

Tumor suppressive effects of GAS5 in cancer cells
by: Kaur, Jesminder, et al.
Published: (2022)

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
by: Geyer, Felipe C., et al.
Published: (2018)

Protocatechuic acid induces apoptosis in human osteosarcoma cells by regulating P13K/AKT/ROS pathway
by: Mei, Qiyuan, et al.
Published: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ge4pjdfdllbjs5f18n0e49aia5