Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach

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Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach

Off-target binding connotes the binding of a small molecule of therapeutic significance to a protein target in addition to the primary target for which it was proposed. Progressively such off-targeting is emerging to be regular practice to reveal side effects. Chymase is an enzyme of hydrolase class...

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Bibliographic Details
Main Authors:	Arooj, Mahreen, Sakkiah, S., Cao, G., Kim, S., Arulalapperumal, V., Lee, K.
Format:	Journal Article
Published:	John Wiley & Sons, Inc. 2015
Online Access:	http://hdl.handle.net/20.500.11937/50090

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