Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

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Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

BACKGROUND AND PURPOSE: Activation of pro-inflammatory transcription factors NF-κB and signal transducer and activator of transcription 3 (STAT3) is one of the major contributors to both pathogenesis and chemoresistance in multiple myeloma (MM), which results in high mortality rate. Thus, in the pre...

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Bibliographic Details
Main Authors:	Kannaiyan, R., Hay, H., Rajendran, P., Li, F., Shanmugam, M., Vali, S., Abbasi, T., Kapoor, S., Sharma, A., Kumar, Alan Prem, Chng, W., Sethi, G.
Format:	Journal Article
Published:	John Wiley & Sons 2011
Online Access:	http://hdl.handle.net/20.500.11937/49947

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