Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
BACKGROUND AND PURPOSE: Activation of pro-inflammatory transcription factors NF-κB and signal transducer and activator of transcription 3 (STAT3) is one of the major contributors to both pathogenesis and chemoresistance in multiple myeloma (MM), which results in high mortality rate. Thus, in the pre...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
John Wiley & Sons
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/49947 |