Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo

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Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo

Cumulative evidences(s) have established that the constitutive activation of STAT3 plays a pivotal role in the proliferation, survival, metastasis, and angiogenesis and thus can contribute directly to the pathogenesis of hepatocellular carcinoma (HCC). Thus, novel agents that can inhibit STAT3 activ...

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Bibliographic Details
Main Authors:	Rajendran, P., Li, F., Shanmugam, M., Kannaiyan, R., Goh, J., Wong, K., Wang, W., Khin, E., Tergaonkar, V., Kumar, Alan Prem, Luk, J., Sethi, G.
Format:	Journal Article
Published:	American Association for Cancer Research 2012
Online Access:	http://hdl.handle.net/20.500.11937/49936

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