Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

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Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4

Background: Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related deaths. Thus, novel agents that can downregulate the CXCR4/CXCL12 axis have the...

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Bibliographic Details
Main Authors:	Manu, K., Shanmugam, M., Rajendran, P., Li, F., Ramachandran, L., Hay, H., Kannaiyan, R., Swamy, S., Vali, S., Kapoor, S., Ramesh, B., Bist, P., Koay, E., Lim, L., Ahn, K., Kumar, Alan Prem, Sethi, G.
Format:	Journal Article
Published:	BioMed Central Ltd. 2011
Online Access:	http://hdl.handle.net/20.500.11937/49916

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