RNA interference therapeutics for cancer: challenges and opportunities

QR Code

RNA interference therapeutics for cancer: challenges and opportunities

Abstract. RNA interference (RNAi) is a sequence-specific, post-transcriptional gene silencing mechanism in animals and plants, which is mediated by double-stranded RNA (dsRNA). There has recently been an increasing interest in harnessing the gene silencing activity of dsRNA to develop novel drugs fo...

Full description

Bibliographic Details
Main Authors:	Bora, R., Gupta, D., Mukkur, Trilochan, Saini, K.
Format:	Journal Article
Published:	Spandidos Publications 2012
Subjects:	target specificity short interfering RNA short interfering RNA delivery gene silencing cancer RNA interference
Online Access:	http://www.spandidos-publications.com/mmr/6/1/9 http://hdl.handle.net/20.500.11937/49685

Similar Items

Characterization of miR-3099-mediated posttranscriptional of target genes regulation during neurogenesis in mice
by: Zainal Abidin, Shahidee
Published: (2019)

Influence of ARHGEF3 and RHOA Knockdown on ACTA2 and Other Genes in Osteoblasts and Osteoclasts
by: Mullin, B., et al.
Published: (2014)

Development of miRNA-mimic nanoparticles for the treatment of brain tumours
by: Anithiya Ramamoorthi Gopalram, Shubaash
Published: (2017)

Development and application of a linear polyamidoamine-SiRNA delivery system
by: Fathi, Zainab H
Published: (2018)

Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
by: Capel, Victoria, et al.
Published: (2016)

Combination therapy using plasmid DNA-mediated VP3 and SHCD147 genes for colon cancer in a murine model
by: Ismail, Ruzila
Published: (2014)

Development of delayed ripening papaya (Carica papaya L.) CV. 'eksotika' using RNA interference and antisense technologies
by: Sekeli, Rogayah
Published: (2013)

MicroRNA Regulation in the Inflammatory Response
by: Martin, Athena
Published: (2023)

Identifying potential RNA editing sites from RNA-Sequencing data from human brain tissue
by: North, Francesca Louise
Published: (2018)

Part A: RNA Therapeutics. Development and challenges in nanoparticle delivery/ Part B: Synthesis and characterisation of supramolecular polyplexes for mRNA delivery
by: Vasudevan, Akshaya
Published: (2024)

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs
by: Dhir, Ashish, et al.
Published: (2015)

Investigating Current Delivery Vehicles for Efficient and Targeted Delivery of Therapeutic RNA and Future Perspectives Part A - Investigating current delivery vehicles for efficient and targeted delivery of therapeutic RNA and future perspectives/ Part B - The development of novel polymeric nanoparticles as efficient non-viral RNA delivery vectors
by: Sachan, Isha
Published: (2023)

Characterisation and Intercellular Mechanistic Analysis of Supramolecular, Cationic, mRNA-Loaded Polyplexes for Efficient Transfection in HEK293T and A549 Cells
by: Smith, Silvia
Published: (2023)

RNAi-mediated gene silencing of lanosterol 14α- demethylase (ERG11)-encoding gene in ganoderma boninense
by: Lim, Fook Hwa
Published: (2022)

RNA interference silencing of interleukin-6 in mesenchymal stromal cells and antitumour efficacy against multiple myeloma cells
by: Teoh, Hoon Koon
Published: (2015)

Sugar-coated nanoparticles: Investigating lipid-terminated glycopolymers for targeted nanoparticle delivery of nucleic acids
by: Fiedler, Benjamin
Published: (2024)

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
by: Capel, Victoria, et al.
Published: (2018)

Optimization Of RNA Extraction And Generation Of Expressed Sequence Tags From Sargassum Binderi (Sonder) J. Agardh
by: Wong, Tony Kok Min
Published: (2005)

Reference-free assembly of long-read transcriptome sequencing data with RNA-Bloom2
by: Nip, K.M., et al.
Published: (2023)

Molecular biology approaches to quantify subcellular localisation of mRNA therapeutics
by: Smart, Alfredo D.
Published: (2025)

Synthesis and Advanced Characterisation of Nanoparticle Gene Delivery Systems for mRNA therapeutics
by: Khosravi, Rahman
Published: (2025)

Development of a stable T7 RNA polymerase expressing cell line using a lentivirus system
by: Yeong, Ming Yue
Published: (2019)

Investigating the roles of long-non-coding RNA genes in zebrafish haematopoiesis
by: Alzaqqah, Fatemah
Published: (2020)

Study on Liposomes Integrity and Delivery of siRNA to Lung Cancer
by: Aljasser, Abdullah
Published: (2024)

Changes in transcription and phospho-signalling in breast tumour hypoxia and hypoxia-reoxygenation
by: Aboalmaaly, Amna
Published: (2024)

Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection
by: Cong, Wei, et al.
Published: (2017)

Exploring the biological functions of vtRNA 1-1
by: Wainwright, Thomas
Published: (2023)

Evidence for an ancient aquatic origin of the RNA viral order Articulavirales
by: Petrone, M.E., et al.
Published: (2023)

Correlation between HPV infection and human beta-defensin mRNA expression in pterygium and normal conjunctiva epithelial cells
by: Aliyu, Abubakar Saadatu
Published: (2017)

Purification of enzyme and influence of substrate specificity on â-1,6-glucanase gene expression in Trichoderma harzianum
by: Mustafa, Muskhazli, et al.
Published: (2009)

Engineering a Mastoparan Peptide Concatemer Prodrug From CircRNA for Cancer Therapy
by: Grewcock, Declan
Published: (2023)

The role of miRNA regulation in response to hypoxia in gliomas
by: Smith, Louise
Published: (2023)

In-vitro investigations into endocytosis and silencing of siRNA-liposomes
by: ALSHEHRI, ABDULLAH ALI D
Published: (2017)

Exploiting Multicomponent Polymerisations for Non-Viral Gene Delivery
by: O'Shaughnessy, Lewis
Published: (2025)

(E)-Vinylphosphonates: nuclease-stable phosphate mimics for effective single-stranded RNA gene silencing
by: Al-Kadhimi, Mustafa M.
Published: (2020)

The synthesis of vinylphosphonate-linked RNA
by: Collis, Alana E.C.
Published: (2008)

Targeting tumour-astrocyte crosstalk for rational identification of novel therapeutic targets for atypical Teratoid/ Rhabdoid tumours
by: Porter, Harry
Published: (2025)

A non-proteolytic role for ubiquitin in deadenylation by the RNA-binding E3 ligase MEX-3C
by: Cano, Florencia, et al.
Published: (2015)

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
by: Haussmann, Irmgard U., et al.
Published: (2016)

The molecular impact of physical exercise on a rodent model of schizophrenia: hippocampal gene expression and miRNA levels
by: Bisnauthsing, Hemlata
Published: (2019)