N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis

N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis

Oxidative stress is implicated as a factor that increases necrosis of skeletal muscles in Duchenne Muscular Dystrophy (DMD) and thedystrophic mdx mouse. Consequently, drugs that minimize oxidative stress are potential treatments for muscular dystrophy. This studyexamined the in vivo benefits to mdx...

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Bibliographic Details
Main Authors: Terrill, J., Crabb, Hannah, Grounds, M., Arthur, P.
Format: Journal Article
Published: Elsevier Ltd 2012
Subjects:
N-Acetylcysteine
Oxidative stress
mdx Mouse
Duchenne Muscular Dystrophy
Treadmill exercise
Protein thiol oxidation
Online Access:http://hdl.handle.net/20.500.11937/49499

Internet

http://hdl.handle.net/20.500.11937/49499

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