Is Cholesterol and Amyloid-[beta] Stress Induced CD147 Expression a Protective Response? Evidence that Extracellular Cyclophilin A Mediated Neuroprotection is Reliant on CD147

Is Cholesterol and Amyloid-[beta] Stress Induced CD147 Expression a Protective Response? Evidence that Extracellular Cyclophilin A Mediated Neuroprotection is Reliant on CD147

The CD147 protein is a ubiquitous multifunctional membrane receptor. Expression of CD147, which is regulated by sterol carrier protein, reportedly modulates amyloid- (A), the neurotoxic peptide implicated in neuronal degeneration in Alzheimer’s disease (AD). Given that high fat/cholesterol is linked...

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Bibliographic Details
Main Authors: Kanyenda, L., Verdile, Giuseppe, Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S.
Format: Journal Article
Published: IOS Press 2014
Subjects:
Alzheimer’s disease
A42
cyclophilin A
neuroprotection
cholesterol
CD147
Online Access:http://iospress.metapress.com/content/d3h15g7rh2473202/
http://hdl.handle.net/20.500.11937/49252

Internet

http://iospress.metapress.com/content/d3h15g7rh2473202/
http://hdl.handle.net/20.500.11937/49252

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