The platelet receptor CLEC-2 is active as a dimer

The platelet receptor CLEC-2 is active as a dimer

The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. Binding of either of these ligands promotes phosphorylation of a single tyrosine residue in the YXXL motif in the intracellular domain of CLEC-2. Phosphorylation of this tyrosine ini...

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Bibliographic Details
Main Authors: Watson, A., Christou, C., James, J., Fenton-May, A., Moncayo, G., Mistry, A., Davis, S., Gilbert, R., Chakera, Aron, O'Callaghan, C.
Format: Journal Article
Published: American Chemical Society 2009
Online Access:http://hdl.handle.net/20.500.11937/4827

Internet

http://hdl.handle.net/20.500.11937/4827

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