The Scar-in-a-Jar: studying potential anti?brotic compounds from the epigenetic to extracellular level in a single well

QR Code

The Scar-in-a-Jar: studying potential anti?brotic compounds from the epigenetic to extracellular level in a single well

Background and purpose: Fibrosis, a pathological accumulation of collagen in tissues, represents a major global disease burden. Effective characterization of potential antifibrotic drugs has been constrained by poor formation of the extracellular matrix in vitro, due to tardy procollagen processing...

Full description

Bibliographic Details
Main Authors:	Chen, C., Peng, Y., Wang, Z., Fish, P., Kaar, J., Koepsel, R., Russell, A., Lareu, Ricardo, Raghunath, M.
Format:	Journal Article
Published:	Stockton Press 2009
Subjects:	bioimaging Fibrosis high content screening macromolecular crowding drug discovery collagen quantitation
Online Access:	http://hdl.handle.net/20.500.11937/47489

Similar Items

Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: The biological relevance of the excluded volume effect
by: Lareu, Ricky R., et al.
Published: (2007)

Suberoylanilide hydroxamic acid – a potential epigenetic therapeutic agent for lung fibrosis?
by: Wang, Z., et al.
Published: (2009)

Emulating a crowded intracellular environment in vitro dramatically improves RT-PCR performance
by: Lareu, Ricky R., et al.
Published: (2007)

Collagen solubility testing, a quality assurance step for reproducible electro-spun nano-fibre fabrication. A technical note
by: Zeugolis, D., et al.
Published: (2008)

Extraction of collagen from fish waste and determination of its physico-chemical characteristics / Nurul Asyiraf Abdul Jabar
by: Abdul Jabar, Nurul Asyiraf
Published: (2011)

Extraction of collagen from catfish (Clarias gariepnus) waste and determination of its physico-chemical properties / Normah Ismail and Nurul Asyiraf Abdul Jabar
by: Ismail, Normah, et al.
Published: (2012)

Porous macromolecular dihydropyridyl frameworks exhibiting catalytic and halochromic activity
by: Xiao, Bo, et al.
Published: (2014)

Essential modification of the Sircol Collagen Assay for the accurate quantification of collagen content in complex protein solutions
by: Lareu, Ricky R., et al.
Published: (2010)

Cost-Effectiveness of Carrier Screening for Cystic Fibrosis in Australia
by: Norman, Richard, et al.
Published: (2012)

A spatio-temporal learning approach for crowd activity modelling to detect anomalies
by: Rao, Arjun
Published: (2009)

Redesign of collagen casings for high quality performance using food grade polysaccharides
by: Sobanwa, Motolani
Published: (2022)

Porous scaffolds and soft hydrogel scaffolds for soft tissue engineering
by: Yang, Yang
Published: (2018)

The potential therapeutic effect of manipulating the extracellular matrix in idiopathic pulmonary fibrosis
by: Philp, Christopher J.
Published: (2016)

Characterising Fish Collagen for Expression in Bacterial Systems
by: Shi, Xiaoqin
Published: (2025)

A process analysis of how the founders of innovative new ventures use sensemaking to develop and manage a crowdfunding campaign in pursuit of campaign legitimacy
by: Gott, Richard
Published: (2020)

Microstructural and Compositional Features of the Fibrous and Hyaline Cartilage on the Medial Tibial Plateau Imply a Unique Role for the Hopping Locomotion of Kangaroo
by: He, Bo, et al.
Published: (2013)

Extraction and characterization of acetic acid-soluble collagen and papain-soluble collagen hydrolysate from poultry eggshell membrane
by: Ma, Roazita
Published: (2016)

Economic evaluation of a community-based diagnostic pathway to stratify adults for non-alcoholic fatty liver disease: a Markov model informed by a feasibility study
by: Tanajewski, Lukasz, et al.
Published: (2017)

Emotional impact of crowding and coping behavior of visitors at Kukup Island National Park, Johor, Malaysia
by: Rosli, Noor Haslidawati
Published: (2016)

Collective interaction filtering with graph-based descriptors for crowd behaviour analysis
by: Wong, Pei Voon
Published: (2018)

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response
by: Roberts, Maxine J., et al.
Published: (2018)

Identifying collagen bundles in the most superficial layer of normal articular cartilage
by: Duan, X., et al.
Published: (2009)

Characterization and physicochemical properties of collagen extracted from barramundi (Lates calcarifer, block) skin
by: Mohamad Razali, Umi Hartina
Published: (2012)

Quality of rail passenger experience: the direct and spillover effects of crowding on individual well-being and organisational behaviour
by: Mohd Mahudin, Nor Diana
Published: (2012)

The effect of aging on crowded letter recognition in the peripheral visual field
by: Astle, Andrew T., et al.
Published: (2014)

Folate-mediated macromolecule delivery across the epithelium
by: Moradi, Emilia
Published: (2012)

Calcium oxalate crystallization in synthetic urinary medium: the impact of resorcinares and calixarenes
by: Bottrill, Odin, et al.
Published: (2022)

Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system
by: Wang, Tao, et al.
Published: (2013)

International comparative epidemiology of idiopathic pulmonary fibrosis
by: Hutchinson, John
Published: (2017)

Production and characterization of collagen and gelatin from edible jellyfish (Acromitus hardenbergi Stiasny, 1934) for fabrication of biofunctional scaffold
by: Khong, Nicholas Mun Hoe
Published: (2014)

Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin
by: Robinson, Henry Duncan
Published: (2021)

A three-pronged approach to virus discovery
by: Hill, Jack Douglas
Published: (2024)

An investigation of the factors that influence participation in mammography screening in Greece
by: Kaltsa, Aikaterina
Published: (2011)

Behavioural responses to lung cancer screening
by: Young, Ben
Published: (2019)

Run spot run: capturing and tagging footage of a race by crowds of spectators
by: Flintham, Martin D., et al.
Published: (2015)

Determinants of intention to adopt online crowdfunding services among SMEs in Northwestern Nigeria
by: Kazaure, Mansur Ahmed
Published: (2021)

Refining in-vivo models of pulmonary fibrosis
by: Habgood, Anthony
Published: (2018)

Novel haemodynamic structures in the human glomerulus
by: Neal, C.R., et al.
Published: (2018)

Collagen modified porous pHEMA–TiO2 composite hydrogels for tissue engineering
by: Li, Chao, et al.
Published: (2013)

THE KAPIT'S BUKTI KEJAYAAN PELA JAR
by: MPRC, Pusat Media & Perhubungan Awam
Published: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ujqj8lntdu920m6r02vnam6scb