Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1, 5-a][1,3,5]triazines as thymidine phosphorylase inhibitors
5-Chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines were designed as new thymidine phosphorylase inhibitors based on the fragment based drug design approach. Multiple-step convergent synthetic schemes were devised to generate the target compounds. The intermediate 5-chloro-6-chloromethyluracil was...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier Masson SAS
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/47444 |