Comparative analysis of the surface interaction properties of the binding sites of CDK2, CDK4 and ERK2

Comparative analysis of the surface interaction properties of the binding sites of CDK2, CDK4 and ERK2

Recently developed hydrogen-bonding and hydrophobic analysis algorithms were used to investigate the interaction properties of the ATP binding sites of CDK2, CDK4, and ERK2. We were able to prioritise those hydrogen-bonding groups that are observed to bind the native ATP ligand, as well as to identi...

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Bibliographic Details
Main Authors: Kelly, M., Mancera, Ricardo
Format: Journal Article
Published: Wiley-VCH Verlag GmbH & Co. KGaA 2006
Subjects:
CDKs
inhibitors
hydrophobic effect
drug design
hydrogen bonds
Online Access:http://hdl.handle.net/20.500.11937/47295

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