Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

BACKGROUND AND PURPOSE: Aberrant activation of STAT3 is frequently encountered and promotes proliferation, survival, metastasis and angiogenesis in hepatocellular carcinoma (HCC). Here, we have investigated whether emodin mediates its effect through interference with the STAT3 activation pathway in...

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Bibliographic Details
Main Authors: Subramaniam, A., Shanmugam, M., Ong, T., Li, F., Perumal, E., Chen, L., Vali, S., Abbasi, T., Kapoor, S., Ahn, K., Kumar, Alan Prem, Hui, K., Sethi, G.
Format: Journal Article
Published: Stockton Press 2013
Subjects:
proliferation
apoptosis
emodin
hepatocellular carcinoma
STAT3
Online Access:http://hdl.handle.net/20.500.11937/46674

Internet

http://hdl.handle.net/20.500.11937/46674

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