HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

Maraviroc (MVC) inhibits the entry of human immunodeficiency virus type 1 (HIV-1) by binding to and modifying the conformation of the CCR5 extracellular loops (ECLs). Resistance to MVC results from alterations in the HIV-1 gp120 envelope glycoproteins (Env) enabling recognition of the drug-bound con...

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Bibliographic Details
Main Authors: Roche, M., Jakobsen, M., Sterjovski, J., Ellett, A., Posta, F., Lee, B., Jubb, B., Westby, M., Lewin, S., Ramsland, Paul, Churchill, M., Gorry, P.
Format: Journal Article
Published: 2011
Online Access:http://hdl.handle.net/20.500.11937/46649

Internet

http://hdl.handle.net/20.500.11937/46649

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