Development of a liquid chromatography/mass spectrometry methodology to separate, detect, characterize and quantify PEG-resveratrol prodrugs and the conjugation reaction precursors and intermediates

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Development of a liquid chromatography/mass spectrometry methodology to separate, detect, characterize and quantify PEG-resveratrol prodrugs and the conjugation reaction precursors and intermediates

A simple and reliable liquid chromatography/mass spectrometry (LC/MS) method to monitor pegylation of resveratrol is described. The developed LC/MS method can separate and quantify unmodified MeO-PEG-OH, carboxylic acid terminated PEG, resveratrol and PEG-resveratrol prodrugs. This methodology was a...

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Bibliographic Details
Main Authors:	Basavaraj, S., Benson, Heather, Cruickshank, C., Brown, David, Chen, Yan
Format:	Journal Article
Published:	John Wiley & Sons Ltd 2011
Online Access:	http://hdl.handle.net/20.500.11937/46416

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