Development of a liquid chromatography/mass spectrometry methodology to separate, detect, characterize and quantify PEG-resveratrol prodrugs and the conjugation reaction precursors and intermediates
A simple and reliable liquid chromatography/mass spectrometry (LC/MS) method to monitor pegylation of resveratrol is described. The developed LC/MS method can separate and quantify unmodified MeO-PEG-OH, carboxylic acid terminated PEG, resveratrol and PEG-resveratrol prodrugs. This methodology was a...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
John Wiley & Sons Ltd
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/46416 |