Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice

Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice

Background - Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also associated with increasing circulating lipid levels and intracellular lipid accumulation modulates DC function. Whether age-associated increases...

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Bibliographic Details
Main Authors: Gardner, Joanne, Mamotte, Cyril, McGonigle, T., Dye, Danielle, Jackaman, Connie, Nelson, Delia
Format: Journal Article
Published: BioMed Central Ltd. 2014
Subjects:
Immunosenescence
Aged mice
Dendritic cell
Lipid uptake
Online Access:http://www.immunityageing.com/content/11/1/11
http://hdl.handle.net/20.500.11937/45376

Internet

http://www.immunityageing.com/content/11/1/11
http://hdl.handle.net/20.500.11937/45376

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