Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography–mass spectrometry

Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography–mass spectrometry

Racemic methadone (MET) is administered to heroin users undergoing methadone maintenance therapy (MMT) in Australia. The enantiomers of methadone possess different pharmacological effects, and the enantioselective metabolism of methadone to its two major metabolites, 2-ethylidene-1,5-dimethyl-3,3-di...

Full description

Bibliographic Details
Main Authors: Kelly, Tamsin, Doble, P., Dawson, M.
Format: Journal Article
Published: Elsevier 2005
Subjects:
Methadone
AGP
Artificial neural networks
EMDP
EDDP
-Glycoprotein
LC–MS
Hair
Chiral
Online Access:http://hdl.handle.net/20.500.11937/44826

Internet

http://hdl.handle.net/20.500.11937/44826

Similar Items