Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

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Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

Background: Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and resistance to glucocorticoids (GCs). We have recently observed that GC resistance in T-ALL cell lines is associated with a prolife...

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Bibliographic Details
Main Authors:	Beesley, A., Rampellini, J., Palmer, Misty-Lee, Heng, J., Samuels, A., Firth, M., Ford, J., Kees, U.
Format:	Journal Article
Published:	BioMed Central Ltd. 2010
Online Access:	http://hdl.handle.net/20.500.11937/44803

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