Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia
Background: Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and resistance to glucocorticoids (GCs). We have recently observed that GC resistance in T-ALL cell lines is associated with a prolife...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
BioMed Central Ltd.
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/44803 |