Synthesis and Antileukemic Activity of New Fluorinated 5-Aza-9-deazapurines

QR Code

Synthesis and Antileukemic Activity of New Fluorinated 5-Aza-9-deazapurines

Novel fluorinated 4-benzylamino-7-phenylpyrazolo[1,5-a]- [1,3,5]triazin-2-amines were prepared using an efficient and practical approach. The chemoselectivity of condensation of pyrazolylguanidine and trichloroacetonitrile was found to be solvent-dependent and, when conducted in toluene, this reacti...

Full description

Bibliographic Details
Main Authors:	Lim, F., Kow, K., Yeo, E., Chow, S., Dolzhenko, Anton
Format:	Journal Article
Published:	The Japan Institute of Heterocyclic Chemistry 2016
Online Access:	http://hdl.handle.net/20.500.11937/44647

Similar Items

Pyrazolo[1,5-a][1,3,5]triazines(5-Aza-9-deazapurines): Synthesis and Biological Activity
by: Dolzhenko, Anton, et al.
Published: (2008)

A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines
by: Lim, F., et al.
Published: (2018)

A novel multicomponent microwave-assisted synthesis of 5-aza-adenines
by: Dolzhenko, Anton, et al.
Published: (2013)

A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates:selective synthesis of substituted 5-aza-9-deaza-adenines
by: Lim, Felicia Phei Lin, et al.
Published: (2018)

A multicomponent reaction of 2-aminoimidazoles: Microwave-assisted synthesis of novel 5-aza-7-deaza-adenines
by: Lim, F., et al.
Published: (2017)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

Advances in chemistry and biological activity of fluorinated 1,3,5-triazines
by: Dolzhenko, Anton, et al.
Published: (2012)

Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines
by: Dolzhenko, Anton, et al.
Published: (2015)

A multicomponent reaction of 2-aminoimidazoles: microwave-assisted synthesis of novel 5-aza-7- deaza-adenines†‡
by: Lim, Felicia Phei Lin, et al.
Published: (2017)

Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines.
by: Dolzhenko, Anton, et al.
Published: (2008)

Antileukemic properties of spermacoce species
by: Sukari, Mohd Aspollah, et al.
Published: (2013)

Antileukemic activity of extracts and constituents of Aegle marmelos
by: Mustahil, Noorul Adawiyah, et al.
Published: (2013)

Antileukemic activity and chemical constituents of some Zingiberaceae species
by: Md.Sukari, Mohd. Aspollah, et al.
Published: (2010)

4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: a new practical synthesis and biological activity
by: Lim, Felicia Phei Lin, et al.
Published: (2014)

Synthesis of New Heterocyclic System: 1(5)H-1,5-Diazacycl[3.3.2]azine-2,4-dione
by: Dolzhenko, Anton, et al.
Published: (2007)

New developments in the 1-aza-Diels-Alder reaction : versatile routes to pyridines
by: Hurst, Timothy E.
Published: (2008)

Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds
by: Ryan, James, et al.
Published: (2016)

Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
by: Rahman, Heshu Sulaiman, et al.
Published: (2013)

Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines
by: Nik Man, Nik Muhd Khuzaimi, et al.
Published: (2015)

Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines
by: Dolzhenko, Anton, et al.
Published: (2007)

Highly selective and efficient synthesis of 3-arylamino-substituted 5-aminopyrazole-4-carboxylates under microwave irradiation
by: Lim, F., et al.
Published: (2016)

Synthesis of 3-(5-amino-1H-1,2,4-triazol-3-yl)propanamides and their tautomerism
by: Lim, F., et al.
Published: (2018)

A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles
by: Lim, F., et al.
Published: (2015)

Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines.
by: Dolzhenko, Anton, et al.
Published: (2007)

A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines
by: Dolzhenko, Anton, et al.
Published: (2009)

A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation
by: Lim, F., et al.
Published: (2016)

Synthesis of 5,7-Diamino[1,2,4]triazolo[1,2-a][1,3,5]triazines via Annulation of 1,3,5-Triazine Ring onto 3(5)-Amino-1,2,4-trizoles
by: Dolzhenko, Anton, et al.
Published: (2007)

A new practical synthesis of 3-amino-substituted 5-aminopyrazoles and their tautomerism
by: Phei, Felicia Lin Lim, et al.
Published: (2019)

Synthesis of novel trichloromethyl substituted azolo[1,3,5]triazines
by: Kalinin, D., et al.
Published: (2012)

Nano-Engineering of New Photoreactive Materials Having Fluorine Units: Synthesis and Photoalignment of Liquid Crystals
by: M. M., Yusoff, et al.
Published: (2013)

One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism
by: Lim, F., et al.
Published: (2018)

Synthesis and structure of 3,4-dihydropyrido[2’,3’:3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines
by: Dolzhenko, Anton, et al.
Published: (2012)

New methods for the construction of fluorinated cyclic amines and amides
by: Charlesworth, Natalie
Published: (2022)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines
by: Lim, F., et al.
Published: (2018)

A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide
by: Kalinin, D., et al.
Published: (2013)

Arranging an enantioselective aza-[2,3]-Wittig rearrangement
by: Davies, Elizabeth Anne
Published: (2009)

An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles
by: Dolzhenko, Anton, et al.
Published: (2009)

New One-Pot Synthesis of 1,3,5-Triazines: Three-Component Condensation, Dimroth Rearrangement, and Dehydrogenative Aromatization
by: Ahmad Junaid,, et al.
Published: (2019)

Synthesis and tautomerism study of 6-benzoylmethyl-1,3,5-triazin-2,4-diamine
by: Sachdeva, N., et al.
Published: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4m02tr9aamdhtg6qgmc5j1n73k