Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties
The Wnt pathway is integrally involved in regulating self-renewal, proliferation, and maintenance of cancer stem cells (CSCs). We explored the effect of the Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), in modulating epithelial to mesenchymal transition (EMT) in CSCs from human gliobl...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Public Library of Science
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/44633 |