Free Energy Calculations of the Interactions of c-Jun-based Synthetic Peptides with the c-Fos Protein

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Free Energy Calculations of the Interactions of c-Jun-based Synthetic Peptides with the c-Fos Protein

The c-Fos–c-Jun complex forms the activator protein 1 transcription factor, a therapeutic target in the treatment of cancer. Various synthetic peptides have been designed to try to selectively disrupt the interaction between c-Fos and c-Jun at its leucine zipper domain. To evaluate the binding affin...

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Bibliographic Details
Main Authors:	Zuo, Zhili, Gandhi, Neha, Arndt, K., Mancera, Ricardo
Format:	Journal Article
Published:	John Wiley and Sons, Inc. 2012
Online Access:	http://hdl.handle.net/20.500.11937/43767

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