Free Energy Calculations of the Interactions of c-Jun-based Synthetic Peptides with the c-Fos Protein
The c-Fos–c-Jun complex forms the activator protein 1 transcription factor, a therapeutic target in the treatment of cancer. Various synthetic peptides have been designed to try to selectively disrupt the interaction between c-Fos and c-Jun at its leucine zipper domain. To evaluate the binding affin...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
John Wiley and Sons, Inc.
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/43767 |