Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury

Thioredoxin (Trx) is a redox-active protein with anti-inflammatory effects but with a short half life of 1 h. Genetic fusion of Trx to human serum albumin (HSA) extended its half life without causing significant loss of its biological activities. HSA–Trx caused a decrease in the number of cells in b...

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Main Authors: Furukawa, M., Tanaka, R., Chuang, Victor, Ishima, Y., Taguchi, K., Watanabe, H., Maruyama, T., Otagiri, M.
Format: Journal Article
Published: Elsevier 2011
Online Access:http://hdl.handle.net/20.500.11937/43717
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author Furukawa, M.
Tanaka, R.
Chuang, Victor
Ishima, Y.
Taguchi, K.
Watanabe, H.
Maruyama, T.
Otagiri, M.
author_facet Furukawa, M.
Tanaka, R.
Chuang, Victor
Ishima, Y.
Taguchi, K.
Watanabe, H.
Maruyama, T.
Otagiri, M.
author_sort Furukawa, M.
building Curtin Institutional Repository
collection Online Access
description Thioredoxin (Trx) is a redox-active protein with anti-inflammatory effects but with a short half life of 1 h. Genetic fusion of Trx to human serum albumin (HSA) extended its half life without causing significant loss of its biological activities. HSA–Trx caused a decrease in the number of cells in brochoalveolar lavage fluid, the wet/dry ratio and the inflammation at the respiratory tract of the ovalbumin (OVA) induced lung injury model mouse. Three intraperitoneal doses of Trx alone produced the same extent of suppression of those three detrimental effects of OVA as one intravenous dose of HSA–Trx. Inhibition experiments confirmed that reactive oxygen species (ROS) and reactive nitrogen species (RNS) involved in the progression of the injury. HSA–Trx inhibited the production of ROS as confirmed in the EPR experiment, but lung tissue staining suggested that induced nitrogen oxide synthase (iNOS) was not suppressed by the fusion protein. Instead, the production of nitrotyrosine, 8-nitro-cGMP, and 8-hydroxy-2′-deoxyguanosine downstream to the iNOS has been inhibited. This suggested that HSA–Trx produced lung protection effect via different mechanisms from Trx alone. HSA–Trx retains the biological properties of Trx thus has great potential in treating oxidative stress related diseases.
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spelling curtin-20.500.11937-437172017-09-13T16:01:02Z Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury Furukawa, M. Tanaka, R. Chuang, Victor Ishima, Y. Taguchi, K. Watanabe, H. Maruyama, T. Otagiri, M. Thioredoxin (Trx) is a redox-active protein with anti-inflammatory effects but with a short half life of 1 h. Genetic fusion of Trx to human serum albumin (HSA) extended its half life without causing significant loss of its biological activities. HSA–Trx caused a decrease in the number of cells in brochoalveolar lavage fluid, the wet/dry ratio and the inflammation at the respiratory tract of the ovalbumin (OVA) induced lung injury model mouse. Three intraperitoneal doses of Trx alone produced the same extent of suppression of those three detrimental effects of OVA as one intravenous dose of HSA–Trx. Inhibition experiments confirmed that reactive oxygen species (ROS) and reactive nitrogen species (RNS) involved in the progression of the injury. HSA–Trx inhibited the production of ROS as confirmed in the EPR experiment, but lung tissue staining suggested that induced nitrogen oxide synthase (iNOS) was not suppressed by the fusion protein. Instead, the production of nitrotyrosine, 8-nitro-cGMP, and 8-hydroxy-2′-deoxyguanosine downstream to the iNOS has been inhibited. This suggested that HSA–Trx produced lung protection effect via different mechanisms from Trx alone. HSA–Trx retains the biological properties of Trx thus has great potential in treating oxidative stress related diseases. 2011 Journal Article http://hdl.handle.net/20.500.11937/43717 10.1016/j.jconrel.2011.05.013 Elsevier restricted
spellingShingle Furukawa, M.
Tanaka, R.
Chuang, Victor
Ishima, Y.
Taguchi, K.
Watanabe, H.
Maruyama, T.
Otagiri, M.
Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
title Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
title_full Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
title_fullStr Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
title_full_unstemmed Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
title_short Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
title_sort human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
url http://hdl.handle.net/20.500.11937/43717