Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits

Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits

PRESENILIN1 (PSEN1) is the major locus for mutations causing familial Alzheimer's disease (FAD) and is also mutated in Pick disease of brain, familial acne inversa and dilated cardiomyopathy. It is a critical facilitator of Notch signalling and many other signalling pathways and protein cleavag...

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Bibliographic Details
Main Authors: Newman, M., Wilson, L., Verdile, Giuseppe, Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M.
Format: Journal Article
Published: Oxford University Press 2014
Online Access:http://hdl.handle.net/20.500.11937/42933

Internet

http://hdl.handle.net/20.500.11937/42933

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