Expression, Characterization, and Evaluation of a RANK-binding Single Chain Fraction Variable: An Osteoclast Targeting Drug Delivery Strategy

Expression, Characterization, and Evaluation of a RANK-binding Single Chain Fraction Variable: An Osteoclast Targeting Drug Delivery Strategy

A single chain Fraction variable (scFv) employs antibody-like target recognition specificity. Osteoclasts, responsible for bone resorption, express Receptor Activator of Nuclear factor Kappa B (RANK) receptors. This study aimed to express, characterize, and evaluate scFv against RANK receptors that...

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Bibliographic Details
Main Authors: Newa, M., Lam, M., Bhandari, K., Xu, B., Doschak, Michael
Format: Journal Article
Published: American Chemical Society 2014
Subjects:
RANK receptor
drug delivery system
phage display
single chain fraction variable
osteoclast
Online Access:http://hdl.handle.net/20.500.11937/42612

Internet

http://hdl.handle.net/20.500.11937/42612

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