Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity
Amyloid-ß (Aß-{42}), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the trea...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
IOS Press
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/42488 |
| _version_ | 1848756433491853312 |
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| author | Dubey, A. Bharadwaj, Prashant Varghese, J. MacReadie, I. |
| author_facet | Dubey, A. Bharadwaj, Prashant Varghese, J. MacReadie, I. |
| author_sort | Dubey, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Amyloid-ß (Aß-{42}), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Aß-{42}. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide. © 2009 - IOS Press and the authors. All rights reserved. |
| first_indexed | 2025-11-14T09:12:07Z |
| format | Journal Article |
| id | curtin-20.500.11937-42488 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T09:12:07Z |
| publishDate | 2009 |
| publisher | IOS Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-424882017-09-13T14:26:11Z Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity Dubey, A. Bharadwaj, Prashant Varghese, J. MacReadie, I. Amyloid-ß (Aß-{42}), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Aß-{42}. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide. © 2009 - IOS Press and the authors. All rights reserved. 2009 Journal Article http://hdl.handle.net/20.500.11937/42488 10.3233/JAD-2009-1121 IOS Press restricted |
| spellingShingle | Dubey, A. Bharadwaj, Prashant Varghese, J. MacReadie, I. Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| title | Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| title_full | Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| title_fullStr | Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| title_full_unstemmed | Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| title_short | Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| title_sort | alzheimer's amyloid-ß rescues yeast from hydroxide toxicity |
| url | http://hdl.handle.net/20.500.11937/42488 |