Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART
HIV-infected individuals responding to antiretroviral therapy (ART) after severe CD4+ T-cell depletion may retain low responses to recall antigens [eg: cytomegalovirus (CMV)] and altered expression of T-cell co-stimulatory molecules consistent with immunosenescence. We investigated the capacity of p...
| Main Authors: | , , |
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| Format: | Journal Article |
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2011
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| Online Access: | http://hdl.handle.net/20.500.11937/4217 |
| _version_ | 1848744453765857280 |
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| author | Fernandez, S. French, M. Price, Patricia |
| author_facet | Fernandez, S. French, M. Price, Patricia |
| author_sort | Fernandez, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | HIV-infected individuals responding to antiretroviral therapy (ART) after severe CD4+ T-cell depletion may retain low responses to recall antigens [eg: cytomegalovirus (CMV)] and altered expression of T-cell co-stimulatory molecules consistent with immunosenescence. We investigated the capacity of phenotypically senescent cells to generate cytokines in HIV patients receiving long-term ART (n = 18) and in healthy controls (n = 10). Memory T-cells were assessed by interferon (IFN)-γ ELISpot assay and flow cytometrically via IFN-γ or IL-2. Proportions of CD57brightCD28null CD4+ T-cells correlated with IFN-γ responses to CMV (p = 0.009) and anti-CD3 (p = 0.002) in HIV patients only. Proportions of CD57brightCD28null CD8+ T-cells and CD8+ T-cell IFN-γ responses to CMV peptides correlated in controls but not HIV patients. IL-2 was predominantly produced by CD28+T-cells from all donors, whereas IFN-γ was mostly produced by CD57+ T-cells. The findings provide evidence of an accumulation of immunosenescent T-cells able to make IFN-γ. This may influence the pathogenesis of secondary viral infections in HIV patients receiving ART. |
| first_indexed | 2025-11-14T06:01:43Z |
| format | Journal Article |
| id | curtin-20.500.11937-4217 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:01:43Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-42172017-09-13T14:44:36Z Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART Fernandez, S. French, M. Price, Patricia HIV-infected individuals responding to antiretroviral therapy (ART) after severe CD4+ T-cell depletion may retain low responses to recall antigens [eg: cytomegalovirus (CMV)] and altered expression of T-cell co-stimulatory molecules consistent with immunosenescence. We investigated the capacity of phenotypically senescent cells to generate cytokines in HIV patients receiving long-term ART (n = 18) and in healthy controls (n = 10). Memory T-cells were assessed by interferon (IFN)-γ ELISpot assay and flow cytometrically via IFN-γ or IL-2. Proportions of CD57brightCD28null CD4+ T-cells correlated with IFN-γ responses to CMV (p = 0.009) and anti-CD3 (p = 0.002) in HIV patients only. Proportions of CD57brightCD28null CD8+ T-cells and CD8+ T-cell IFN-γ responses to CMV peptides correlated in controls but not HIV patients. IL-2 was predominantly produced by CD28+T-cells from all donors, whereas IFN-γ was mostly produced by CD57+ T-cells. The findings provide evidence of an accumulation of immunosenescent T-cells able to make IFN-γ. This may influence the pathogenesis of secondary viral infections in HIV patients receiving ART. 2011 Journal Article http://hdl.handle.net/20.500.11937/4217 10.3233/DMA-2011-0847 fulltext |
| spellingShingle | Fernandez, S. French, M. Price, Patricia Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART |
| title | Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART |
| title_full | Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART |
| title_fullStr | Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART |
| title_full_unstemmed | Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART |
| title_short | Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART |
| title_sort | immunosenescent cd57 +cd4+ t-cells accumulate and contribute to interferon-γ responses in hiv patients responding stably to art |
| url | http://hdl.handle.net/20.500.11937/4217 |