Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac

QR Code

Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac

This study demonstrates the effectiveness of a peptide shuttle in delivering diclofenac into and through human epidermis. Diclofenac was conjugated to a novel phenylalanyl-N-methyl-naphthalenylalanine-derived diketopiperazine (DKP) shuttle and to TAT (a classical cell penetrating peptide), and topic...

Full description

Bibliographic Details
Main Authors:	Mohammed, Y., Teixido, M., Namjoshi, S., Giralt, E., Benson, Heather
Format:	Journal Article
Published:	Public Library of Science 2016
Online Access:	http://hdl.handle.net/20.500.11937/4171

Similar Items

Enhanced transdermal delivery of a dipeptide by Dermaportation
by: Namjoshi, Sarika, et al.
Published: (2008)

Magnetophoresis: Skin penetration enhancement by a magnetic field
by: Benson, Heather, et al.
Published: (2017)

Sunscreens: efficacy, skin penetration and toxicological aspects
by: Benson, Heather
Published: (2008)

Enhanced Transdermal Delivery of 5-Aminolevulinic Acid and a Dipeptide by Iontophoresis
by: Krishnan, Gayathri, et al.
Published: (2011)

Enhanced Transdermal Delivery of 5-Aminolevulinic Acid and a Dipeptide by Iontophoresis
by: Krishnan, Gayathri, et al.
Published: (2011)

Proteins and peptides: Strategies for delivery to and across the skin
by: Benson, Heather, et al.
Published: (2008)

Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies
by: Abd, E., et al.
Published: (2018)

Skin penetration enhancement techniques
by: Krishnan, Gayathri
Published: (2011)

Formulation Effects on Topical Nanoparticle Penetration
by: Benson, Heather, et al.
Published: (2016)

Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles
by: Leite-Silva, V., et al.
Published: (2016)

Enhanced Skin Permeation of Naltrexone by Pulsed Electromagnetic Fields in Human Skin In Vitro
by: Krishnan, Gayathri, et al.
Published: (2010)

Skin Structure, Function, and Permeation
by: Benson, Heather
Published: (2012)

Enhanced anti-inflammatory effects of nanoencapsulated diclofenac
by: Goh, Jun Zheng, et al.
Published: (2013)

Skin Electroporation
by: Benson, Heather, et al.
Published: (2008)

Transdermal delivery of vaccines
by: Namjoshi, Sarika, et al.
Published: (2011)

Dipeptide and xanthones from Artocarpus kemando Miq.
by: Mohd Hashim, Najihah, et al.
Published: (2011)

Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment
by: Leite-Silva, V., et al.
Published: (2016)

Evaluation of the skin penetration behaviour of sunscreen actives
by: Ab. Hadi, Hazrina, et al.
Published: (2015)

Analysing the Skin Barrier from Down Under
by: Grice, J., et al.
Published: (2013)

Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin
by: Mohammed, Yousuf, et al.
Published: (2014)

Minoxidil skin delivery from nanoemulsion formulations containing eucalyptol or oleic acid: Enhanced diffusivity and follicular targeting
by: Abd, E., et al.
Published: (2018)

Shuttle iot: UTAR bus management system
by: Chin, Pei Shan
Published: (2024)

Enhanced transdermal peptide delivery and stability by lipid conjugation: Epidermal permeation, stereoselectivity and mechanistic insights
by: Namjoshi, S., et al.
Published: (2014)

Involvement Of Mitochondria In Diclofenac – And Ibuprofen- Induced Hepatotoxicity
by: Moorthy, Mohanambal
Published: (2008)

Novel cyclic undecapeptides immobilized on reduced graphene oxide surface for enhanced antibacterial properties
by: Farrag, H. N., et al.
Published: (2023)

Topical and transdermal drug delivery: From simple potions to smart technologies
by: Benson, Heather, et al.
Published: (2019)

Synthesis of dipeptide benzoylalanylglycine methyl ester and corrosion inhibitor evaluation by Tafel equation
by: Juniarti Abdurrahman,, et al.
Published: (2011)

Targeted delivery of cell penetrating peptide virus-like nanoparticles to skin cancer cells
by: Gan, Bee Koon, et al.
Published: (2018)

Design of a Band-Stop Filter for a Space Shuttle Vehicle
by: Shi, Y., et al.
Published: (2015)

Modelling the Diclofenac and Indomethacin Recovery by Molecularly Imprinted Polymer
by: Nurlin, Abu Samah, et al.
Published: (2018)

Morphological alteration in mitochondria following diclofenac and ibuprofen administration.
by: Moorthy, Mohanambal, et al.
Published: (2008)

Histopathologic toxicity evaluation of liposome-encapsulated diclofenac sodium
by: Goh, Jun Zheng, et al.
Published: (2014)

Genetic analysis of genes involved in dipeptide metabolism and cytotoxicity in Pseudomonas aeruginosa PAO1
by: Kiely, P., et al.
Published: (2008)

An improved technique for experimental infections with skin penetrating nematode larvae (Necator americanus)
by: Behnke, Jerzy M., et al.
Published: (1986)

Topical nano and microemulsions for skin delivery
by: Nastiti, Christofori, et al.
Published: (2017)

Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia
by: Cruzat, Vinicius, et al.
Published: (2014)

Influence of Partially Standing Waves on Offloading Operations for Shuttle Tanker
by: Patel, M.S., et al.
Published: (2020)

Unravelling the Shuttling Mechanism in a Photoswitchable Multicomponent Bistable Rotaxane
by: Raiteri, Paolo, et al.
Published: (2008)

Developing an understanding of redox-shuttle mediators in lithium-metal batteries
by: Vailaya, Ganesh
Published: (2025)

74 pemain sertai kejohanan badminton 'let’s shuttle 2024!'
by: Utusan, Sarawak
Published: (2024)

Cannot write session to /tmp/vufind_sessions/sess_47bchj9rhg1l1uaa6mffgi5v4p