Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models

QR Code

Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models

Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68+ KC, play a key role in the induction of hepatic oxidative stress and injuries, we newly developed a polythiolated- and mannosylated-human serum albumin (SH-Man-HSA), a novel nano-antioxidant for delivering thiol to...

Full description

Bibliographic Details
Main Authors:	Maeda, H., Hirata, K., Watanabe, H., Ishima, Y., Chuang, Victor, Taguchi, H., Inatsu, A., Kinoshita, M., Tanaka, M., Sasaki, Y., Otagiri, M., Maruyama, T.
Format:	Journal Article
Published:	American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:	Kupffer cells antioxidants drug delivery macrophages liver disease
Online Access:	http://hdl.handle.net/20.500.11937/40655

Similar Items

Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions
by: Minayoshi, Y., et al.
Published: (2018)

Formation, morphology and function of a 3D hepatocyte-hepatic stellate cell co-culture system
by: Thomas, Robert James
Published: (2006)

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2014)

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer
by: Kinoshita, R., et al.
Published: (2017)

Potential use of human serum albumin as a drug delivery systems
by: Ishima, Y., et al.
Published: (2015)

Relationship between renal CD68+ infiltrates and the Oxford Classification of IgA nephropathy
by: Soares, M., et al.
Published: (2019)

Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition
by: Ikeda, M., et al.
Published: (2016)

Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury
by: Furukawa, M., et al.
Published: (2011)

Immunomodulatory action of new curcumin analogue [2,6-BIS(2,5-dimethoxybenzylidene) cyclohexanone] on major inflammatory mediator expression in activated macrophage and synovial fibroblast cells
by: Lee, Ka Heng
Published: (2012)

Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis
by: Tanaka, R., et al.
Published: (2014)

S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes
by: Kinoshita, R., et al.
Published: (2015)

A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis
by: Ikeda, M., et al.
Published: (2018)

Pharmaceutical Aspects of the Recombinant Human Serum Albumin Dimer: Structural Characteristics, Biological Properties, and Medical Applications
by: Taguchi, K., et al.
Published: (2012)

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy
by: Crittenden, Marka R., et al.
Published: (2016)

Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery
by: Ichimizu, S., et al.
Published: (2018)

Biological characteristics of two lysines on human serum albumin in the high affinity binding of m4Z,15Z-bilirubin-Ix[alpha] revealed by phage display
by: Minomo, A., et al.
Published: (2011)

Biological characteristics of two lysines on human serum albumin in the high affinity binding of m4Z,15Z-bilirubin-Ix[alpha] revealed by phage display
by: Minomo, A., et al.
Published: (2011)

Albumin fusion of thioredoxin - The production and evaluation of its biological activity for potential therapeutic applications
by: Ikuta, S., et al.
Published: (2010)

Prevalence of classical CD14++/CD16 - But not of intermediate CD14++/CD16 + monocytes in hypoalphalipoproteinemia
by: Sala, F., et al.
Published: (2013)

Characterisation of the modulation of immune response to polymer implants using established and novel methods
by: Suvannapruk, Waraporn
Published: (2023)

Combining extracellular matrix hydrogels and electrical stimulation to influence macrophage polarisation
by: Whitehead, Charlie D.
Published: (2024)

CD4/CD8 Ratios among Blood Donors in Penang
by: Musa, M, et al.
Published: (1990)

Electrodeposited CdS/CdTe solar cells
by: Mohamad, Souad A.
Published: (2011)

Therapeutic impact of human serum albumin-thioredoxin fusion protein on influenza virus-induced lung injury mice
by: Tanaka, R., et al.
Published: (2014)

Finite difference calculation of electron states in CdTe-CdS core-shell quantum dots
by: Woon, C.Y, et al.
Published: (2011)

Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages
by: Günther, Juliane, et al.
Published: (2016)

A study of microparticle shape and surface chemistry effects on interactions with macrophages
by: Bruce, Gordon
Published: (2021)

Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis
by: Keane, Timothy J., et al.
Published: (2017)

Investigating predation by the predatory bacterium Bdellovibrio bacteriovorus at the interface between predatory bacteria, pathogenic prey, and the host immune response
by: Clark, Callum
Published: (2023)

Immune-instructive polymers for modulating macrophage phenotype
by: Alromaihi, Reem
Published: (2024)

Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists
by: Bewley, Martin A., et al.
Published: (2018)

Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease
by: Shibata, A., et al.
Published: (2016)

Circulating CD14+ and CD14highCD16− classical monocytes are reduced in patients with signs of plaque neovascularization in the carotid artery
by: Ammirati, E., et al.
Published: (2016)

Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2
by: Katsara, M., et al.
Published: (2008)

Impaired Upregulation of the Costimulatory Molecules, CD27 and CD28, on CD4(+) T Cells from HIV Patients Receiving ART Is Associated with Poor Proliferative Responses.
by: Tanaskovic, S., et al.
Published: (2016)

Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases
by: Nagumo, K., et al.
Published: (2014)

Redox properties of serum albumin
by: Anraku, M., et al.
Published: (2013)

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
by: Jackaman, Connie, et al.
Published: (2013)

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity
by: Tanaka, K., et al.
Published: (2018)

Biological characteristics of two lysines on human serum albumin in the high-affinity binding of 4Z, 15Z-bilirubin-IXa revealed by phage display
by: Minomo, A., et al.
Published: (2011)

Cannot write session to /tmp/vufind_sessions/sess_o0japnl2nol8o8r4kfklf8vi3m