Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models

Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models

Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68+ KC, play a key role in the induction of hepatic oxidative stress and injuries, we newly developed a polythiolated- and mannosylated-human serum albumin (SH-Man-HSA), a novel nano-antioxidant for delivering thiol to...

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Bibliographic Details
Main Authors: Maeda, H., Hirata, K., Watanabe, H., Ishima, Y., Chuang, Victor, Taguchi, H., Inatsu, A., Kinoshita, M., Tanaka, M., Sasaki, Y., Otagiri, M., Maruyama, T.
Format: Journal Article
Published: American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:
Kupffer cells
antioxidants
drug delivery
macrophages
liver disease
Online Access:http://hdl.handle.net/20.500.11937/40655

Internet

http://hdl.handle.net/20.500.11937/40655

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